Aptamers are relevant biotechnological tools in many fields : health, cosmetics, environmental sciences (enzyme inhibitor, label, probe, biosensor...). In 2005, the IECB team “Small RNA & Aptamers” (INSERM U869) assembled the first automated platform for aptamer selection in France, an equipement that speeds up the selection from 3 months to 2 weeks. In order to develop biotechnological applications of aptamers, the team created Novaptech, it was initialy a technology transfer unit associated to the lab. Since 2017 Novaptech is a society and has been collaborating with academic and private labs, using aptamer-based tools against proteins, peptides, small molecules, toxins or nucleic acids :
Service agreements
- Identification of aptamers (RNA, DNA, chemically modified oligonucleotides) through an automated in vitro process)
- Optimization of selected aptamers by minimizing their size and improving nuclease resistance,
- Conjugation of aptamers to biotin, fluorophore, amine, thiol groups.
Biotechnological development of aptamers
- Development of new tools in analytical, diagnostic (sensoring. imaging) or therapeutic fields.
Collaborative research projects
- Implementation of new strategies to promote and develop the use of aptamers
- Improvement of the automated platform by developing new procedures and components.
Sectors of activity
- Healthcare & biology
- Environment
- Food & nutrition
- Diagnostic & imaging
- Chemistry & pharmaceutical
- Cosmetics
Applications
- Molecular probes for imaging
- Biosensors
- Target validation, drug delivery, drug discovery
- Therapeutic agent
- Research (affinity purification, cell sorting, protein-binding RNA sites, ELONA)
|
